Thailand has had JE vaccination for many years. The presence of JE antibodies in JE endemic countries can also affect the efficacy of dengue vaccination. What is your view on this, given dengue vaccine efficacy data from JE endemic countries?

During the Active Phase of CYD14, efficacy by country was consistent with the overall estimate the VE against VCD. The point estimates of VE in Thailand was similar to those in Philippines and in Indonesia, where no public JE vaccination program is implemented. It is still unclear whether pre-exposure of other flaviviruses could affect the efficacy or immune responses of dengue vaccines.